I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. He has been very lethargic, he was an extremely playful pup. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). Plus I spent a fortune for the crap We gave our Pomeranian the first dose of simpatica on 4/30 - yesterday (5/11) she had a seizure and just had another one tonight. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. We have been gradually increasing the dose but it hasnt helped. I wish every one the best. Nothing they can do for her she said. I have a vet appointment tomorrow to figure it out. And urinating more often as a result. Dr said either Simparica (best case scenario), GOLPP or brain tumor. She still has her appetite at the moment. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. She had some good days and we were hopeful but ultimately, she steadily declined. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. Took to vet and she said it could be the Simparico Trio. He was a Shih Tzu. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Im still confused. How long did it last with your dog? Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. How is your puppy doing? Her blood work came back fine. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. Hi Chelsea, I am hopeful that your Shepherd has recovered. So sorry! She had the treatment yesterday and seemed ok. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. Normal. I just hope he has a turn around . Today June 1,2022 she is still having neurological problems. The cardiologist found no heart condition that would cause this. Can someone please tell me if their dogs got better after taking the pill? He scratched at them which made it worse. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. Very "out of it". With Entyce she is getting her appetite back and seems a little better. I tried everything but she just didnt have an appetite for anything. I dont want to have to put my dog down but hes suffering. This is terrible. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! For dogs with a history of seizures: consider carefully. A few months back he started with a morning vomiting always on his empty tummy. We are experiencing the same thing. She is only 6 and was so full of life and energy. I will be discontinuing the medication. Does anybody know how long this will last? A month later, he was at doggie daycare and we picked him up and he was panting frantically. He is my first dog, he is 5yrs old now, and this is all new. Is it just me or does it seem like everyone is in this together? Since then I've researched loads and as you say the FDA put out a report. Again he has diarrhea and this month he seems agitated or nervous. Sorry but keeping it caged due to a suspected side effect is is uncalled for. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Did you go to the vets or not? Itching has decreased immensely. My personal dog has had no issues at all, and she's been on it for nearly two years. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. I just gave Bentlee my Akita Simparica Trio on the 9th. Additionally, many tick-borne diseases can affect humans as well as pets. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. Especially after seeing these post. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. He has been drinking more water then usual. This crap is poison! . On 01/07/21, we gave our 11 year old black lab, Rawley, a 2nd dose of Simparico TRIO. The company is reimbursing for vet costs. Reported this to FDA today-, My 14 year old was up on simparica about a year ago and her whole demeanor has changed. This sure seems like this happening way too often . around 12 years She grabs and won't let go. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! I am also going to contact the vet who gave it to me and tell him all this stuff. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. And how long for this sheet to get out of the dogs system??? He is just laying in his crate . Glad i held off on the free sample i was given! I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. Any suggestion? Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! The king cavalier bichon mix seems to be ok just not eating much if at all. I advise all pet owners to know the side effects. This is because it doesn't kill adult heartworms. Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. What Are Potential Simparica Trio Side Effects in Dogs? We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. Humans are another matter. Use a collar or topical if you need to. Last month she had diarrhea and it lasted 7 days. Overly anxious. I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. Then they come back! Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. Needless, to say I will not be giving them the simparica trio again. I just gave him heartgard and nexgard about 2 weeks with no issues. I took her home. I thought maybe my dog had a bladder infection or got into something that upset her gut. He had a problem with severe biting a few months back and Vet said he most likely allergic to fleas (bites). He first started with seizures and losing weight in June after giving him Simparica. Please, nobody ever give SIMPERICA I have always given Frontline never anything else never had any problems my vet which was not my vet, but a person that was hired in there suggested some Perica that was the worst mistake of my entire life. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. Sorry to hear about this happening to so many. Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. Things like: Bloody Diarrhea In a margin of safety study, Simparica was administered orally to 8-week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28-day intervals for 10 doses. All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. So sorry! Our pick for best oral flea control product for dogs is Simparica TRIO, a chewable tablet that is fast-acting and kills more parasites than any other oral product. She has good days and bad days but she is far from the dog she use to be. Anyone else have the same eye issues? My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. I guarantee he will not take this trash again. I did find another one in New Hampshire but I know like everyone else that all we be negative just like all tests done so far. I just wanted them gone and for him to feel better. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. Hope your dog is doing well .my dog had clear neurological changes after taking Simparica trio .his tounge just hangs out of his mouth now and that was never the case prior to Simparica,also has tremors and shakes he never previously experienced.also major weight gain even though no increase in diet .i decided to take my pet off of simparico even though the vet strongly engouraged we remain on it even though i explained the symptoms and changes I noticed in my pet ! My dog has had 3 seizures in the past from wearing a flea collar. Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. I feel like it was a massive overdose. I am going to try stopping the medication for a month to see if things improve. He has been on just Simparica with no problems. Im convinced the medicine caused this and now she cant walk. Thannks !! Mine is. Simparica Trio is just one of many parasite prevention products on the market for dogs. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Then I saw this and realized. In other words, they can make it easier to have a seizure in susceptible dogs. This junk needs to be pulled from the market. If it was due to the Simparica, then it would expected to be resolved within a day or two. All three drugs are pesticides that work by attacking the nervous system of the fleas and ticks, causing death. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. I say yes! Our dog was killed by this poison within 15 hours after taking one dose. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. Seizures are going on two hours.. He had gone to a new groomer and when he came home he had a seizure. Before sharing sensitive information, make sure you're on a federal government site. Two weeks after first simparica dose.parasites gone. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. They want another blood draw in 3 weeks to see where she is. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. We are now at about 45 days since last simparica and he is back to his old self. Since she is young, the vet started us with Keppra. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. He is otherwise normal and healthy. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. Our 3 mo.old Boston Terrier, 10 lbs, had her first dose of Simparaco yesterday. It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. The site is secure. I called the vet and they said it was likely brought on by stress. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. She definitely is not herself and behaving strangely. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. Never any issues with bravecto so we'll return to that medication. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. The other has had diarrhea every since 6 hours after the pill. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." I can tell something is off with her I just couldnt figure it out. Other signs may include: Lethargy Loss of appetite My 2 1/2 mini goldendoodle has been on Simparica 10 days now. What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. She never did that before! Hi, I was just wondering how long you continued on with the steroids with your puppy. If fact it specifically states on the product label "Not for use in humans". First time for this adverse reaction. I gave my dog his first dose April 8th. She text me asking if she ever had seizures before. She had terrible vomiting and diarrhea for a week and also weakness and staggering three weeks later. I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. Hello! Are there any side effects to Simparica Trio? Then he came too . Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. My dog is on a "health care plan" with my vet. Her protein levels dropped to almost nothing and stomach filled with fluid. The vet office called simparica hotline to find out if it was safe to give her another one. 3 months ago he began having seizures, he had one every day for a week. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. Hoping that these side effects dont get worse and subside soon . Related questions. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. . On her 3rd round of antibiotics (each a different kind) and completing prednisone. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. She is still eating but she is drinking more water. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. My dog (6 years old) has been using monthly Simparica since I got him. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. How common are Simparica side effects? My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. My vet never mentioned that puppies under 6months cannot be prescribed this medication. Has anyone had a dermatitis issue as a result of Simparica? It seems to be clearing up with Rx eye drops. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. My family saw it , I did not . Buddy 8 year old male Boxer formerly energetic and playful. I took him to the ER they checked his vitals and sent me home. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. I just want to cry! For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? It comes as the first choice when prescribing a treatment due to its liver flavor. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. Unfortunately, I didn't realize the tremors were possibly caused by the drug. By the evening she lost the use of her hind legs. I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. After reading all your entries, i'm thrilled i chose to take her off of it. Saturday he started up the drinking again and threw up his breakfast. I came across this site and read so much about symptoms that I now realize he has been having. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. He had full wellness exam three ago and was in perfect shape. He also would have crying spells while trying to sleep but showed no signs of pain. The third ingredient in Simparica Trio is. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. Gave Simparica to my dog yesterday. I will NEVER give this drug to my dogs! Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. So scary. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. Some are also approved for treatment and control of ear mite infestations and some gastrointestinal parasite infections, and a few are also approved for prevention of heartworm disease. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. I feel like she's been an experiment to make others money. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. Next she developed severe tremors. I'm using milk thistle and broccoli sprout powder, and going forward I'm going to use HWF Clean Heart for heartworm prevention. Mine is due for another dose next week and I don't know what to do. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. Revolution has been around decades with less incidents of animal reactions. Although these products can and have been. Puppy Simparico Trio for the first time 2 days ago. I need to tell my vet to switch! Just be aware that no oral tick medicine is safe, all are from the same class of drugs. Previously B was on Heartgard and Advantix worked well I guess we switch back. Im petrified after reading the comments here. Twice I have seen his eyes roll into the back of his head (petti-mal seizure?) I gave my six-year-old dog SIM perica because the combo guard was on back order. We hope this will solve our problems and he can live a healthy and happy life. This medicine needs to be stopped. 2-6 days in vomiting here and there. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. Nothing. We go for more bloodwork today and are praying for better news. After second pill, weve notice he has been a bit down for a couple days. I started crying carrying his body to my husband . I'm so upset. She has been on our property for four year and has survived everything. He already has canine dementia on and off. 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