It is also known its hepatoprotector effect on the Hepatitis type B, C, A, herpes, and HIV. This herb is also effective in treating many other medical conditions. B., Antarkar, D. S., Deolalikar, R., and Antani, D. H. A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen. J Med Virol. View abstract. 2-8-1999;136(1):11-16. With the recent research demonstrating its ability to lower blood pressure and blood sugar, help treat diabetes, enhance liver health, and reduce the risk of developing disease . View abstract. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. Beneficial effects of Phyllanthus amarus for chronic hepatitis B, not confirmed. Orlando G, Chiavaroli A, Ferrante C, et al. Eur Rev Med Pharmacol Sci 2021;25(7):3074-3082. This herb may also counter the effects of norepinephrine. Secondly, it may increase sugar storage in the liver, which reduces blood sugar levels [4, 80, 74, 81]. According to Ayurvedic medicine, chanca piedra is the most promising treatment for kidney stone production. ( Read one of the studies.) Colpo E, Vilanova CD, Pereira RP, et al. Although there is no clinical evidence, chanca piedra lowered both male and . Although there is no clinical evidence, chanca piedra lowered both male and female fertility in mice [1, 162, 163, 164]. Yeh, S. F., Hong, C. Y., Huang, Y. L., Liu, T. Y., Choo, K. B., and Chou, C. K. Effect of an extract from Phyllanthus amarus on hepatitis B surface antigen gene expression in human hepatoma cells. View abstract. Whats more, other small human studies have observed some benefit to taking chanca piedra for kidney stones (4). There isn't enough reliable information to know what an appropriate dose of chanca piedra might be. View abstract. 1993;40(1):53-58. There is little information on specific dosage recommendations, although some literature states 2-3 g/day is a therapeutic dose. Still, this doesnt necessarily mean that chanca piedra would have the same effect in humans. . Chanca piedra may truly act as a stone crusher. According to rat and cell-based studies, it might dissolve kidney stones by [27, 28, 23, 25, 29, 26]: Overall, the available evidence is limited but suggests it works. Although chanca piedra is an herb, it may pose some health risks. with midazolam, some antidepressants, beta-blockers, statins, warfarin, and anti-seizure drugs) [165, 137, 166]. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. In a clinical study on 100 people with hepatitis C, chanca piedra increased multiple important antioxidant compounds (superoxide dismutase, catalase, glutathione, vitamin C, vitamin E). The compounds of the Chanca Piedra plant may provide our bodies with health-promoting properties: diuretic, antiviral, antimicrobial, anti-inflammatory, and detoxifying. SelfDecode is a personalized health report service, You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Some of these organizations include ConsumerLab, NSF International, and United States Pharmacopeia (USP). Adipocytokine regulation and antiangiogenic activity underlie the molecular mechanisms of therapeutic effects of Phyllanthus niruri against non-alcoholic fatty liver disease. View abstract. It enlarged blood vessels and caused kidney damage in rats and mice [159, 160, 161]. Consult with your healthcare provider before taking any new supplements. Supplement Chanca Piedra pills with our Chanca Piedra Stonebreaker Tea! Tamil, I. G., Dineshkumar, B., Nandhakumar, M., Senthilkumar, M., and Mitra, A. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. View abstract. Ibrahim D, Hong LS, Kuppan N. Antimicrobial activity of crude methanolic extract from Phyllanthus niruri. U.S. Food and Drug Administration.Warning Letter: Herbs America, Inc. MARCS-CMS 545913.. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. View abstract. Kidney stones can cause severe pain as well as other symptoms, including cloudy urine, pain during urination, and an urgent need to pee. As such, these products will reflect a higher Shipping Weight compared to the unprotected product. Carlos received his PhD and MS from the Universidad de Sevilla. et Thonn. Patel S, Sharma V, S Chauhan N, Thakur M, Dixit VK. View abstract. View abstract. de Arajo Jnior RF, de Souza TP, Pires JG, et al. View abstract. Pregnant women and women taking fertility-enhancing drugs should avoid taking chanca piedra. Exp Biol Med (Maywood). View abstract. It may lower blood pressure, cholesterol, and heart damage while relaxing and protecting your blood vessels. Preventive effect of Phyllanthus amarus on prostatic hyperplasia. While chanca piedra may reduce blood sugar and blood pressure levels, it should be used with caution if youre already on medication for lowering blood pressure or blood sugar. B. If the gallbladder doesn't empty completely, the remaining particles, like cholesterol or calcium salts, can start to thicken and become biliary. The contents of the bottles and the benefits listed below are the same for both product labels. Chanca piedra is best known as a potential kidney stone cure which is how it earned the name stone breaker.. The nursing mother should take the lowest dose possible. You should also watch for signs of hypoglycemia (low blood sugar). Stop using chanca piedra at least two weeks before a planned surgery. This might increase the risk of blood pressure becoming too low. In clinical studies with over 200 people with kidney stones, chanca piedra (Phyllanthus niruri) reduced their kidney stones, helping to clear the minerals and salt deposits [21, 22, 23, 24, 25, 26]. Diuretic activity of Phyllanthus niruri (Linn.) Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Cealan A, Coman RT, Simon V, et al. Treats kidney stones, gall stones and urinary tract issues. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Virus Res 2011;158(1-2):89-97. Clean, all-natural formula. Taking chanca piedra along with medications that lower blood pressure might cause blood pressure to go too low. Some products may not be standardized. Chanca Piedra is both antiviral and antibacterial. In other studies on rabbits, rats, and cells, chanca piedra reduced blood pressure, prevented excessive platelet clumping, relaxed blood vessels, and improved heart function [67, 68, 69, 70, 71]. Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Qian-Cutrone J, Huang S, Trimble J, et al. One species of chanca piedra Phyllanthus niruri is safe and non-toxic. Due to its antioxidant content, chanca piedra may improve liver function and help protect the liver from cellular damage caused by free radicals unstable compounds that can cause damage when they build up in your body in high levels (1). Notka, F., Meier, G., and Wagner, R. Concerted inhibitory activities of Phyllanthus amarus on HIV replication in vitro and ex vivo. Therapeutic observation of Phyllanthus amarus for treatment of hepatitis B . 1991;12(3):405-406. Heres what you need to. Londhe, J. S., Devasagayam, T. P., Foo, L. Y., and Ghaskadbi, S. S. Antioxidant activity of some polyphenol constituents of the medicinal plant Phyllanthus amarus Linn. Chitra R, Vadivel E Rajamani K. Estimation of anti-hepatic viral compounds in Phyllanthus amarus in vitro cultures. It's essential to take certain precaution while using chanca piedra "Phyllanthus niruri L." supplements. Be sure to consult a healthcare provider if you have any concerns about chanca piedra and pregnancy or breastfeeding. People with type 1 or type 2 diabetes should also use this supplement with caution, as it may decrease blood sugar levels. Phyllanthus niruri, or Chanca Piedra, is a small annual herb that grows and spreads much like a weed; it is native to the rainforests of the Amazon and other tropical areas, including the Bahamas, southern India, and China.Two other species, Phyllanthus amarus and Phyllanthus sellowianus, are closely related to P. niruri in appearance, phytochemical structure, and history of use, but are . 2009;66(4):439-444. Narendranathan M, Mini PC Remla A. Its use in Ayurvedic traditional medicine is well-documented. High herb, phyllanthin and hypophyllanthin yielding variety of bhumyamalaki (Phyllanthus amarus): Cim-Jeevan. Information is shared for educational purposes only. During and after surgery, blood sugar control can be interfered with. In small clinical studies with 30 people,chanca piedra (the Phyllanthus amarus species) lowered their blood sugar levels. Healing and Rejuvenation: It's valued for its healing . . 2002;89(9):829-834. Chanca piedra has been documented in human and animal studies with diuretic effects. Animal and cell-based studies reveal chanca piedra contains powerful antioxidant, anti-inflammatory, anti-cancer, and antibacterial compounds. $29.99. Furthermore, in cells, it blocked the replication of hepatitis C and hepatitis B, HIV-1, herpes virus (HSV-1) and dengue virus [55, 112, 113, 114, 115, 116, 117, 118, 56, 119, 120, 121, 122, 123]. Overall, it may protect the liver by [30, 31, 52, 39, 40, 53, 54, 55, 56]: To sum it up, chanca piedra may help combat viral hepatitis, but its probably not superior to conventional antivirals. Chanca piedra is an herb that grows in tropical areas, like the rainforests of South America. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. chanca piedra dosage for cats. Faremi, T. Y., Suru, S. M., Fafunso, M. A., and Obioha, U. E. Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. The same was confirmed in numerous studies with diabetic rats [57, 73, 74, 75, 76, 48, 77, 62, 78, 63, 79, 66, 71]. View abstract. Larger, more robust clinical trials are needed. It should also not be taken while breastfeeding or by children due to the lack of safety data in these two populations. Innovative Food Science & Emerging Technologies 2010;526-532. Chanca Piedra Powder: 1/2 - 1 tsp. Kidney Stones. All in all, chanca piedra seems to be good for the heart. Effect of Phyllanthus amarus Schum. J Nat Prod 1996;59:196-9. Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri. Sharma, P., Parmar, J., Verma, P., Sharma, P., and Goyal, P. K. Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. However, more research needs to be done. The herb is believed to have health benefits in treating ulcers, urinary tract stones, and various conditions related to the kidneys, liver, and digestive system.. Amariinic acid and related ellagitannins from Phyllanthus amarus. Wongnawa M, Thaina P Bumrungwong N et al. Chanca piedra (Phyllanthus amarus) can increase urination and interfere with the effects of water pills (diuretics); this can result in additional fluid loss [57, 29]. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. View abstract. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Indian J Med Res 1982;76 Suppl:124-130. We have yet to see clinical studies of chanca piedra in people with cognitive dysfunction. Journal of Complementary and Integrative Medicine 2010;7(1). All chanca piedra species are abundant in bioactive components, which carry their purported health benefits. In Brazil, people call it Quebra Pedra, which means stone breaker in Portuguese. Lancet 10-29-1988;2(8618):1017-1018. Lee NY, Khoo WK, Adnan MA, et al. 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